主要成果 | 科研項目(2020-至今) 1. 基於磁共振及納米生物力學表征解析肝癌微血管空間侵襲機製🙁,國家自然科學基金面上項目🥼,82471939☝🏻,2025/01-2028/12,48萬元,主持 2. 肝癌微血管侵犯空間異質性的生物力學機製研究,上海市自然科學基金面上項目,24ZR1447100🙋🏽,2024/10-2027/09,20萬元💁🏻♀️,主持 3. 上海交通大學“交大之星”計劃醫工交叉研究基金重點項目👨🏽🦳,基於磁共振多維生物力學表征預測肝癌免疫分型及轉化治療療效,YG2024ZD04,2024/01-2026/12,100萬元,主持 4. 上海市教育委員會📜,上海高校教師培養計劃-5T超高場MRI技術研發及肝臟臨床應用,2024/07-2025/6,5萬元,主持 5. 上海交通大學醫恒达醫學技術恒达“領航-攀登計劃”項目,面向肝臟局竈性病變自動分割與鑒別的可解釋性深度網絡模型構建,2024/10-2025/11,10萬元,主持 6. 上海市衛生健康委員會,上海市“醫苑新星”青年醫學人才培養資助計劃(醫學影像)🙏,2021.1-2024.12,10萬元🧔🏻,主持 論著(2020-至今🦸♀️;第一或通訊作者) 1. Liu G, Shen Z, Chong H, Zhou J, Zhang T, Wang Y, Ma D, Yang Y, Chen Y, Wang H, Sack I, Guo J, Li R(共同通訊), Yan F. Three-Dimensional Multifrequency MR Elastography for Microvascular Invasion and Prognosis Assessment in Hepatocellular Carcinoma. J Magn Reson Imaging. 2024. Epub ahead of print. 2. Wang R, Wang Y, Qiu S, Ma S, Yan F, Yang GZ, Li R(共同通訊), Feng Y. A Comparative Study of Three Systems for Liver Magnetic Resonance Elastography. J Magn Reson Imaging. 2024. Epub ahead of print. 3. Wang Y, Zhou J, Lin H, Wang H, Sack I, Guo J, Yan F, Li R(共同通訊). Viscoelastic parameters derived from multifrequency MR elastography for depicting hepatic fibrosis and inflammation in chronic viral hepatitis. Insights Imaging. 2024;15(1):91. 4. Fu H, Shen Z, Lai R, Zhou T, Huang Y, Zhao S, Mo R, Cai M, Jiang S, Wang J, Du B, Qian C, Chen Y, Yan F, Xiang X, Li R(共同通訊), Xie Q. Clinic-radiomics model using liver magnetic resonance imaging helps predict chronicity of drug-induced liver injury. Hepatol Int. 2023. 17(6):1626-1636. 5. Liu G, Ma D, Wang H, Zhou J, Shen Z, Yang Y, Chen Y, Sack I, Guo J, Li R, Yan F. Three-dimensional multifrequency magnetic resonance elastography improves preoperative assessment of proliferative hepatocellular carcinoma. Insights Imaging. 2023;14(1):89. 6. Lyu J, Li Y, Yan F, Chen W, Wang C, Li R(共同通訊). Multi-channel GAN-based calibration-free diffusion-weighted liver imaging with simultaneous coil sensitivity estimation and reconstruction. Front Oncol. 2023;13:1095637. 7. Wang Y, Guo J, Ma D, Zhou J, Yang Y, Chen Y, Wang H, Sack I, Li R(共同通訊), Yan F. Reduced tumor stiffness quantified by tomoelastography as a predicative marker for glypican-3-positive hepatocellular carcinoma. Front Oncol. 2022;12:962272. 8. Chen Y, Li R(共同第一), Yang Y, Ma D, Zhou J, Wang C, Kong L, Chen Y, Yan F, Feng Y. Correlation analysis of structural and biomechanical properties of hepatocellular carcinoma tissue. J Biomech. 2022;141:111227. 9. Lin H, Wang Y, Zhou J, Yang Y, Xu X, Ma D, Chen Y, Yang C, Sack I, Guo J, Li R(共同通訊), Yan F. Tomoelastography based on multifrequency MR elastography predicts liver function reserve in patients with hepatocellular carcinoma: a prospective study. Insights Imaging. 2022;13(1):95. 10. Hu X, Zhou J , Li Y, Wang Y,Guo J , Sack S ,Chen W, Yan F, Li R* (共同通訊),Wang C*. Added Value of Viscoelasticity for MRI-Based Prediction of Ki-67 Expression of Hepatocellular Carcinoma. Cancers.2022;14:2575. 11. Wang C, Zheng L, Li Y, Xia S, Lv J, Hu X, Zhan W, Yan F, Li R(共同通訊), Ren X. Noninvasive Assessment of Liver Fibrosis and Inflammation in Chronic Hepatitis B: A Dual-task Convolutional Neural Network (DtCNN) Model Based on Ultrasound Shear Wave Elastography. J Clin Transl Hepatol. 2022;10(6):1077-1085. 12. Liu Q, Zhang B, Wang L, Zheng R, Qiang J, Wang H*, Yan F*, Li R*(共同通訊). Assessment of Vascular Network Connectivity of Hepatocellular Carcinoma Using Graph-Based Approach. Front Oncol. 2021;11:668874. 13. Li W#, Li R#(共同第一), Zhao X#, Lin X, Yu Y, Zhang J, Chen K, Chai W, Yan F. Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging. J Clin Transl Hepatol. 2021;9(3):315-323. 14. Zheng R, Wang L, Wang C, Yu X, Chen W, Li Y, Li W, Yan F, Wang H, Li R. Feasibility of automatic detection of small hepatocellular carcinoma (≤2 cm) in cirrhotic liver based on pattern matching and deep learning. Phys Med Biol. 2021;66(8). doi: 10.1088/1361-6560/abf2f8. 15. Chen Y, Qiu S, He Z, Yan F, Li R*(共同通訊), Feng Y*. Comparative Analysis of Indentation and Magnetic Resonance Elastography for Measuring Viscoelastic Properties. Acta Mechanica Sinica. 2021;37(3):527-536. 申請專利 1. 一種基於不平衡部分特征傳輸的無監督多模態腹部圖像分割方法及系統(排位第1)申請號 202410784422.6 (李若坤董舜傑戴文雯嚴福華張孝勇沈哲涵蒲雨霖) 2. 一種基於不平衡最優傳輸的肝臟局竈性病變診斷方法(排位第1)申請號 202410784429.4 (李若坤、董舜傑🧓、蒲雨霖👷🏻♀️、張雲菲、沈哲涵、嚴福華⛴、鄧林) 3. 一種基於可變形卷積的超低劑量全身醫學影像生成系統(排位第1)申請號 202410784429.4 (李若坤董舜傑蒲雨霖夏季沈哲涵鄧林嚴福華) 4. 一種用於預測增殖型肝細胞癌的模型和諾模圖的構建方法(排位第2)申請號 202310457979.4 5. 影像組學結合深度學習模型的 Ki-67 在肝癌表達中的預測方法(排位第2)申請號 202311013946.7 專著(2020-至今) 1. 2024,上海科學技術出版社,藥物與中毒性肝病(第3版),編委 2. 2024,人民衛生出版社🙎🏿♂️,中華臨床影像鑒別診斷學,編委 3. 2024,科學出版社,普通高等教育案例版系列教材《MR醫學影像診斷學》(編委),ISBN:9787030745385 4. 2023👨🏻🏫✋🏿,復旦大學出版社,《現代體部磁共振診斷學:肝膽胰脾分冊》(副主編)ISBN📸🌌:9787309164701 5. 2023,復旦大學出版社🥭,《現代體部磁共振診斷學:泌尿生殖分冊》(編委)ISBN:9787309159516 |